CP-866087 - An Overview

Contraindicated (1)bortezomib will increase the level or effect of mavacamten by influencing hepatic enzyme CYP2C19 metabolism. Contraindicated. Strong or average CYP2C19 inhibitors may perhaps enhance mavacamten systemic exposure, resulting in coronary heart failure due to systolic dysfunction.

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primidone will minimize the level or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

Normally consult your healthcare company Should you have queries or problems. Using the information on this Internet site would not create a medical doctor-affected individual partnership concerning Most cancers Treatment Ontario and you simply.

rifabutin will lower the extent or result of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

tell your doctor and Health care provider For anyone who is allergic to bortezomib, mannitol, some other medications, boron, or any with the components in bortezomib. Talk to your Health care provider Atpenin A5 for a listing of the ingredients.

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fosamprenavir will improve the stage or outcome of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

There won't be any info on existence of bortezomib or metabolites in human milk, the results in the drug around the breast fed toddler or on milk creation

Sexual reproduction necessitates the mating of two organisms, male and feminine, or maybe the uniting of elements provided by male and feminine organisms.

Diabetic issues mellitus: Sufferers taking oral hypoglycemic brokers are at risk for developing hypo or hyperglycemia when addressed with bortezomib; thus, the blood sugars have to have watchful monitoring.

phenytoin will reduce the level or effect of bortezomib by Ritobegron HCl affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

cenobamate will boost the amount or impact of bortezomib by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Intently. Contemplate a dose reduction of CYP2C19 substrates, Atpenin A5 as clinically appropriate, when utilised concomitantly with cenobamate.

Grade one (asymptomatic; loss of Deep tendon reflexes or paresthesia) with out pain or loss of perform: No motion